Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis

Science. 1998 Oct 23;282(5389):754-9. doi: 10.1126/science.282.5389.754.

Abstract

Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aerobiosis
  • Amino Acid Sequence
  • Amino Acids / biosynthesis
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Biological Evolution
  • Chlamydia trachomatis / classification
  • Chlamydia trachomatis / genetics*
  • Chlamydia trachomatis / metabolism
  • Chlamydia trachomatis / physiology
  • DNA Repair
  • Energy Metabolism
  • Enzymes / chemistry
  • Enzymes / genetics
  • Genome, Bacterial*
  • Humans
  • Lipids / biosynthesis
  • Molecular Sequence Data
  • Peptidoglycan / biosynthesis
  • Peptidoglycan / genetics
  • Phylogeny
  • Protein Biosynthesis
  • Recombination, Genetic
  • Sequence Analysis, DNA*
  • Transcription, Genetic
  • Transformation, Bacterial
  • Virulence

Substances

  • Amino Acids
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Enzymes
  • Lipids
  • Peptidoglycan

Associated data

  • GENBANK/AE001275
  • GENBANK/AE001276
  • GENBANK/AE001277
  • GENBANK/AE001278
  • GENBANK/AE001279
  • GENBANK/AE001280
  • GENBANK/AE001281
  • GENBANK/AE001282
  • GENBANK/AE001283
  • GENBANK/AE001284
  • GENBANK/AE001285
  • GENBANK/AE001286
  • GENBANK/AE001287
  • GENBANK/AE001288
  • GENBANK/AE001289
  • GENBANK/AE001290
  • GENBANK/AE001291
  • GENBANK/AE001292
  • GENBANK/AE001293
  • GENBANK/AE001294
  • GENBANK/AE001295
  • GENBANK/AE001296
  • GENBANK/AE001297
  • GENBANK/AE001298
  • GENBANK/AE001299
  • GENBANK/AE001300
  • GENBANK/AE001301
  • GENBANK/AE001302
  • GENBANK/AE001303
  • GENBANK/AE001304