5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors

J Med Chem. 1998 Jul 2;41(14):2442-4. doi: 10.1021/jm980179c.
No abstract available

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Animals
  • Arginine Vasopressin / antagonists & inhibitors*
  • Arginine Vasopressin / deficiency
  • Azepines / administration & dosage
  • Azepines / chemical synthesis
  • Azepines / metabolism
  • Azepines / pharmacology
  • Benzamides / administration & dosage
  • Benzamides / chemical synthesis
  • Benzamides / metabolism
  • Benzamides / pharmacology
  • Blood Platelets / metabolism
  • Body Water / metabolism
  • Cell Line
  • Cell Membrane / metabolism
  • Dogs
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism
  • Humans
  • Kidney / metabolism
  • Liver / metabolism
  • Osmolar Concentration
  • Pyrroles
  • Rats
  • Receptors, Vasopressin / metabolism*
  • Sodium / blood
  • Structure-Activity Relationship
  • Urine / chemistry

Substances

  • Azepines
  • Benzamides
  • Pyrroles
  • Receptors, Vasopressin
  • Arginine Vasopressin
  • lixivaptan
  • Sodium