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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
J Biol Chem. 1998 May 29;273(22):13375-8. doi: 10.1074/jbc.273.22.13375.
J Biol Chem. 1998.
PMID: 9593664
Free article.
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK.
Myers MP, et al.
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13513-8. doi: 10.1073/pnas.95.23.13513.
Proc Natl Acad Sci U S A. 1998.
PMID: 9811831
Free PMC article.
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