Resveratrol, a remarkable inhibitor of ribonucleotide reductase

FEBS Lett. 1998 Jan 16;421(3):277-9. doi: 10.1016/s0014-5793(97)01572-x.

Abstract

Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.

MeSH terms

  • Animals
  • DNA, Neoplasm
  • Enzyme Inhibitors / pharmacology*
  • Free Radicals
  • Humans
  • Mice
  • Nucleic Acid Synthesis Inhibitors / pharmacology*
  • Recombinant Fusion Proteins / antagonists & inhibitors
  • Recombinant Fusion Proteins / genetics
  • Resveratrol
  • Ribonucleotide Reductases / antagonists & inhibitors*
  • Ribonucleotide Reductases / genetics
  • Stilbenes / pharmacology*
  • Tumor Cells, Cultured
  • Tyrosine / metabolism

Substances

  • DNA, Neoplasm
  • Enzyme Inhibitors
  • Free Radicals
  • Nucleic Acid Synthesis Inhibitors
  • Recombinant Fusion Proteins
  • Stilbenes
  • Tyrosine
  • Ribonucleotide Reductases
  • ribonucleotide reductase R2 subunit
  • Resveratrol