Abstract
Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.
MeSH terms
-
Animals
-
DNA, Neoplasm
-
Enzyme Inhibitors / pharmacology*
-
Free Radicals
-
Humans
-
Mice
-
Nucleic Acid Synthesis Inhibitors / pharmacology*
-
Recombinant Fusion Proteins / antagonists & inhibitors
-
Recombinant Fusion Proteins / genetics
-
Resveratrol
-
Ribonucleotide Reductases / antagonists & inhibitors*
-
Ribonucleotide Reductases / genetics
-
Stilbenes / pharmacology*
-
Tumor Cells, Cultured
-
Tyrosine / metabolism
Substances
-
DNA, Neoplasm
-
Enzyme Inhibitors
-
Free Radicals
-
Nucleic Acid Synthesis Inhibitors
-
Recombinant Fusion Proteins
-
Stilbenes
-
Tyrosine
-
Ribonucleotide Reductases
-
ribonucleotide reductase R2 subunit
-
Resveratrol