Diagnosis and management of canine cortisol-secreting adrenal tumors

Vet Clin North Am Small Anim Pract. 1997 Mar;27(2):299-307. doi: 10.1016/s0195-5616(97)50033-7.

Abstract

Cortisol-secreting adrenal tumors are responsible for 10% to 15% of all cases of naturally occurring canine hyperadrenocorticism. Differentiation of adrenal-dependent hyperadrenocorticism from pituitary-dependent hyperadrenocorticism is very important because the recommended therapeutic approaches for each are different, and the prognosis also may be different. A stepwise approach to diagnosing and staging the disease is needed. Treatment options include surgery and administration of mitotane or ketoconazole.

Publication types

  • Review

MeSH terms

  • Adenoma / diagnosis
  • Adenoma / therapy
  • Adenoma / veterinary*
  • Adrenal Gland Neoplasms / diagnosis
  • Adrenal Gland Neoplasms / therapy
  • Adrenal Gland Neoplasms / veterinary*
  • Adrenal Glands / drug effects
  • Adrenal Glands / surgery
  • Adrenocorticotropic Hormone / blood
  • Animals
  • Antifungal Agents / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Dog Diseases / diagnosis*
  • Dog Diseases / metabolism
  • Dog Diseases / therapy*
  • Dogs
  • Hydrocortisone / blood
  • Hydrocortisone / metabolism*
  • Ketoconazole / therapeutic use
  • Mitotane / therapeutic use
  • Prognosis

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Mitotane
  • Adrenocorticotropic Hormone
  • Ketoconazole
  • Hydrocortisone