Abstract
From extracts of olive (Olea europaea L., Oleaceae) leaves showing anti-complementary activity, the flavonoids apigenin, apigenin-4'-O-rhamnosylglucoside, apigenin-7-O-glucoside, luteolin, luteolin-4'-O-glucoside, luteolin-7-O-glucoside, chrysoeriol, chrysoeriol-7-O-glucoside and quercetin-3-O-rhamnoside were isolated. Major isolated constituents strongly inhibited the classical pathway of the complement system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Complement Inactivator Proteins / pharmacology*
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Complement Pathway, Alternative / drug effects
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Complement Pathway, Classical / drug effects
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Flavonoids / pharmacology*
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Hemolysis / drug effects
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Humans
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Plant Extracts / chemistry
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Plant Leaves / chemistry*
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Plants, Medicinal / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
Substances
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Complement Inactivator Proteins
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Flavonoids
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Plant Extracts