On exploring the basis for slow and fast oscillations in cellular systems

Biophys Chem. 1982 Apr;15(1):9-13. doi: 10.1016/0301-4622(82)87011-7.

Abstract

We show that interesting oscillatory patterns may arise from an immobilized enzyme system, when the enzyme has the properties that it is inhibited by a substrate, produces H+ and has a pH-activity curve of bell-shaped form. In agreement with experimental observations in cellular excitations, the system generates fast oscillations that are superimposed on a slow cycle, at certain salt and enzyme concentrations.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Physiological Phenomena*
  • Electric Organ / physiology
  • Hydrogen-Ion Concentration
  • Kinetics
  • Mathematics
  • Models, Biological
  • Torpedo