Enhancement by retinyl acetate of hormone-induced mammary tumorigenesis in female GR/A mice

J Natl Cancer Inst. 1981 Oct;67(4):935-8.

Abstract

Feeding of retinyl acetate (82 mg/kg ration) for 13-16 weeks to estrone- and progesterone-treated nulliparous and multiparous inbred GR/A mice resulted in a substantial increase in the incidence of mammary carcinomas. Mammary carcinoma incidence in nulliparous control and retinoid-fed mice in experiment #1 was 22/65 (34%) and 37/65 (57%) (P less than 0.05), respectively; in experiment #2, 27/48 (56%) and 37/48 (77%) (P less than 0.05), respectively. Mammary carcinoma incidence in multiparous control and retinoid-fed mice in experiment #1 was 13/30 (43%) and 23/30 (77%) (P less than 0.05), respectively; in experiment #2, 19/19 (100%) and 19/19 (100%), respectively. The purported chemopreventive activities of retinyl acetate in murine mammary tumorigenesis were not demonstrated in this study; indeed, the vitamin A analog appeared to enhance this oncogenic process in the steroid hormone-treated GR mouse mammary cancer model.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cocarcinogenesis
  • Diterpenes
  • Estrone*
  • Female
  • Mammary Neoplasms, Experimental / chemically induced*
  • Mice
  • Mice, Inbred Strains
  • Organ Size / drug effects
  • Parity
  • Progesterone*
  • Retinyl Esters
  • Vitamin A / analogs & derivatives*
  • Vitamin A / pharmacology

Substances

  • Diterpenes
  • Retinyl Esters
  • Vitamin A
  • Estrone
  • retinol acetate
  • Progesterone