Abstract
Mice were given either beta-carotene or either of two carotenoids with no vitamin A activity--canthaxanthin or phytoene--or placebo. Skin tumors were induced in each group by each of three methods: (1) UV-B (290--320 nm); (2) dimethylbenz(a)anthracene (DMBA)/croton oil applications; (3) DMBA followed by low-dose UV-B. For tumors induced by UV-B alone, beta-carotene-phytoene- and canthaxanthin-treated mice developed fewer tumors per mouse, with a delay in tumor appearance, than did control mice. For tumors induced by DMBA/croton oil or DMBA/UV-B, mice receiving beta-carotene showed a significant difference in tumor numbers and appearance time from placebo mice; phytoene and canthaxanthin treatment had no effect.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene
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Animals
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Canthaxanthin
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Carcinoma, Squamous Cell / chemically induced
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Carotenoids / analogs & derivatives
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Carotenoids / metabolism
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Carotenoids / pharmacology*
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Croton Oil
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Female
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Mice
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Mice, Inbred Strains
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Neoplasms, Experimental / chemically induced
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Neoplasms, Radiation-Induced / etiology
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Neoplasms, Radiation-Induced / pathology
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Neoplasms, Radiation-Induced / prevention & control*
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Papilloma / chemically induced
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Skin Neoplasms / chemically induced
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Skin Neoplasms / pathology
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Skin Neoplasms / prevention & control*
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Ultraviolet Rays
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beta Carotene
Substances
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beta Carotene
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Carotenoids
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Canthaxanthin
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9,10-Dimethyl-1,2-benzanthracene
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Croton Oil
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(all-E) phytoene