Two non-allelic human interferon alpha genes with identical coding regions

EMBO J. 1984 Aug;3(8):1809-12. doi: 10.1002/j.1460-2075.1984.tb02050.x.

Abstract

A hitherto undescribed human interferon-alpha (IFN-alpha) gene, IFN-alpha 13, has been isolated and characterized. Its entire coding sequence is completely identical with that of IFN-alpha 1; the 5' and 3' non-coding regions differ by 4.5% and 3.8%, respectively. As the two genes are not allelic, we conclude that the similarity is due to a very recent gene conversion event. Both genes are expressed in virus-induced leukocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • DNA, Recombinant / analysis
  • Gene Conversion
  • Genes*
  • Genetic Linkage
  • Humans
  • Interferon Type I / genetics*
  • Leukocytes / analysis
  • RNA, Messenger / analysis
  • Transcription, Genetic

Substances

  • DNA, Recombinant
  • Interferon Type I
  • RNA, Messenger

Associated data

  • GENBANK/X00803
  • GENBANK/X00804