The structure of eight distinct cloned human leukocyte interferon cDNAs

Nature. 1981 Mar 5;290(5801):20-6. doi: 10.1038/290020a0.

Abstract

Eight classes of human leukocyte interferon (LeIFN) cDNA clones have been identified in a cDNA library prepared from a myeloblastoid cell line. The nucleotide sequences demonstrate that the multiple human LeIFN genes code for a family of homologous, yet distinct proteins. One of the cDNA clones may have been derived from the transcription of a LeIFN pseudogene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • Codon
  • DNA Restriction Enzymes
  • Genes, Synthetic
  • Humans
  • Interferons / genetics*
  • Leukocytes
  • Nucleic Acid Hybridization
  • Protein Precursors / genetics
  • Transcription, Genetic

Substances

  • Codon
  • Protein Precursors
  • Interferons
  • DNA Restriction Enzymes

Associated data

  • GENBANK/J00207
  • GENBANK/J00208
  • GENBANK/J00209
  • GENBANK/J00210
  • GENBANK/J00211
  • GENBANK/J00212
  • GENBANK/J00213
  • GENBANK/J00214
  • GENBANK/V00544