Abstract
In male Sprague-Dawley rats it was tested whether the induction of carcinomas of the bladder by butyl-butanol-nitrosamine (BBN) and the induction of carcinomas of the colon by 1,2-dimethylhydrazine (DMH) could be influenced by an aromatic retinoid ethyl-allyl-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate (RO 10-9359). Neither an inhibitory nor an enhancing effect of the retinoid on carcinogenesis was observed.
MeSH terms
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Animals
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Antineoplastic Agents*
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Carcinogens*
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Cocarcinogenesis*
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Dimethylhydrazines / antagonists & inhibitors
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Dimethylhydrazines / toxicity
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Drug Interactions
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Male
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Neoplasms, Experimental / chemically induced*
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Neoplasms, Experimental / prevention & control
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Nitrosamines / antagonists & inhibitors
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Nitrosamines / toxicity
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Rats
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Vitamin A / analogs & derivatives*
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Vitamin A / therapeutic use
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Vitamin A / toxicity
Substances
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Antineoplastic Agents
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Carcinogens
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Dimethylhydrazines
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Nitrosamines
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Vitamin A