A thorough and current study of miR-214-related targets in cancer

Bayu Indra Sukmana; Sulieman Ibraheem Shelash Al-Hawary; Munther Abosaooda; Mohaned Adile; Reena Gupta; Ebraheem Abdu Musad Saleh; Enas R Alwaily; Hashem O Alsaab; I B Sapaev; Yasser Fakri Mustafa

doi:10.1016/j.prp.2023.154770

A thorough and current study of miR-214-related targets in cancer

Pathol Res Pract. 2023 Sep:249:154770. doi: 10.1016/j.prp.2023.154770. Epub 2023 Aug 22.

Affiliations

¹ Departement of Oral Biology, Lambung Mangkurat University, Banjarmasin, Indonesia.
² Department of Business Administration, Business School, Al al-Bayt University, P.O.BOX 130040, Mafraq 25113, Jordan.
³ College of Pharmacy, The Islamic University, 54001 Najaf, Iraq.
⁴ Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
⁵ Institute of Pharmaceutical Research, GLA University, District-Mathura, Uttar Pradesh 281406, India. Electronic address: rspg80@gmail.com.
⁶ Department of Chemistry, Prince Sattam Bin Abdulaziz University, College of Arts and Science, Wadi Al-Dawasir 11991, Saudi Arabia.
⁷ Microbiology Research Group, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq.
⁸ Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia.
⁹ Tashkent Institute of Irrigation and Agricultural Mechanization Engineers" National Research University, Tashkent, Uzbekistan; New Uzbekistan University, Tashkent, Uzbekistan.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.

PMID: 37660658
DOI: 10.1016/j.prp.2023.154770

Abstract

Cancer is a complex genetic anomaly involving coding and non-coding transcript structural and expressive irregularities. A class of tiny non-coding RNAs known as microRNAs (miRNAs) regulates gene expression at the post-transcriptional level by binding only to messenger RNAs (mRNAs). Due to their capacity to target numerous genes, miRNAs have the potential to play a significant role in the development of tumors by controlling several biological processes, including angiogenesis, drug resistance, metastasis, apoptosis, proliferation, and drug resistance. According to several recent studies, miRNA-214 has been linked to the emergence and spread of tumors. The human genome's q24.3 arm contains the DNM3 gene, which is about 6 kb away and includes the microRNA-214. Its primary purpose was the induction of apoptosis in cancerous cells. The multifaceted and complex functions of miR-214 as a modulator in neoplastic conditions have been outlined in the current review.

Keywords: Cancer progression; MicroRNA-214; Non-coding RNA; Oncogenesis.

Publication types

Review

MeSH terms

Apoptosis
Humans
MicroRNAs* / genetics
Neoplasms* / genetics
RNA, Messenger

Substances

MicroRNAs
RNA, Messenger
MIRN214 microRNA, human