A review on the role of LINC00173 in human cancers

Pathol Res Pract. 2023 Mar:243:154351. doi: 10.1016/j.prp.2023.154351. Epub 2023 Feb 3.

Abstract

Long intergenic non-protein coding RNA 173 (LINC00173) is a long non-coding RNA with especial function in the tumorigenic process. Studies in different types of cancers support an oncogenic role for LINC00173 except for studies in B-cell precursor acute lymphoblastic leukemia, cervical cancer, pancreatic cancer and gastric cancer. In breast and lung cancers, both oncogenic and tumor suppressor roles have been reported for LINC00173. LINC00173 can serve as a molecular sponge for miRNAs. miR-218/Etk, miR-511-5p/VEGFA, miR-182-5p/AGER, miR-765/NUTF2, miR-765/PLP2, miR-182-5p/FBXW7, miR-338-3p/Rab25, miR‑641/RAB14 and miR-1275/BCL2 are examples of the miRNA/mRNA axes being regulated by LINC00173 in the context of cancer. The current review provides a summary of different studies on the role of LINC00173 in these cancers.

Keywords: Biomarker; Cancer; LINC00173.

Publication types

  • Review

MeSH terms

  • Carcinogenesis / genetics
  • Cell Proliferation / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Genes, Tumor Suppressor
  • Humans
  • Lung Neoplasms* / pathology
  • MicroRNAs* / genetics
  • RNA, Long Noncoding* / genetics
  • rab GTP-Binding Proteins

Substances

  • MicroRNAs
  • RNA, Long Noncoding
  • Rab25 protein, human
  • rab GTP-Binding Proteins
  • Rab14 protein, human
  • MIRN1275 microRNA, human
  • MIRN218 microRNA, human
  • MIRN338 microRNA, human
  • MIRN641 microRNA, human
  • MIRN765 microRNA, human