The role of NOD2 in intestinal immune response and microbiota modulation: A therapeutic target in inflammatory bowel disease

Ziyue Liu; Yaqin Zhang; Tao Jin; Chengxue Yi; Dickson Kofi Wiredu Ocansey; Fei Mao

doi:10.1016/j.intimp.2022.109466

The role of NOD2 in intestinal immune response and microbiota modulation: A therapeutic target in inflammatory bowel disease

Int Immunopharmacol. 2022 Dec;113(Pt B):109466. doi: 10.1016/j.intimp.2022.109466. Epub 2022 Nov 23.

Authors

Ziyue Liu¹, Yaqin Zhang¹, Tao Jin², Chengxue Yi³, Dickson Kofi Wiredu Ocansey⁴, Fei Mao⁵

Affiliations

¹ Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
² Department of Gastrointestinal and Endoscopy, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, PR China. Electronic address: mrjt1111@163.com.
³ School of Medical Technology, Zhenjiang College, Zhenjiang, Jiangsu 212028, PR China.
⁴ Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China; Directorate of University Health Services, University of Cape Coast, PMB, Cape Coast, Ghana.
⁵ Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China; Institute of Digestive Diseases, Jiangsu University, Zhenjiang, Jiangsu 212001, PR China. Electronic address: maofei2003@ujs.edu.cn.

PMID: 36435061
DOI: 10.1016/j.intimp.2022.109466

Abstract

As an intracellular pattern recognition receptor (PPR), the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) triggers a cascade of immune responses. Previous studies of NOD2 regarding inflammatory bowel disease (IBD) mainly focused on the relevance of NOD2 mutations and loss within the disease onset and progression. With increasing research, more studies are exploring other functional roles and clinical applications of NOD2. In this review, we discuss the role of NOD2 in intestinal immune response and microbiota modulation in IBD and explore its clinical potential as a therapeutic target for IBD.

Keywords: IBD; Immune response; Microbiota; NOD2; Therapeutic target; miRNA.

Publication types

Review

MeSH terms

Chronic Disease
Humans
Immunity
Inflammatory Bowel Diseases* / therapy
Intestines
Microbiota*
Nod2 Signaling Adaptor Protein / genetics

Substances

NOD2 protein, human
Nod2 Signaling Adaptor Protein