IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models

Helena Ågerstam; Henrik Lilljebjörn; Marianne Rissler; Carl Sandén; Thoas Fioretos

doi:10.3324/haematol.2022.281059

IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models

Haematologica. 2023 Feb 1;108(2):599-604. doi: 10.3324/haematol.2022.281059.

Authors

Helena Ågerstam¹, Henrik Lilljebjörn², Marianne Rissler², Carl Sandén², Thoas Fioretos³

Affiliations

¹ Division of Clinical genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden; Department of Clinical Genetics and Pathology, Office for Medical Services, Region Skåne, Lund. helena.agerstam@med.lu.se.
² Division of Clinical genetics, Department of Laboratory Medicine, Lund University, Lund.
³ Division of Clinical genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden; Department of Clinical Genetics and Pathology, Office for Medical Services, Region Skåne, Lund. thoas.fioretos@med.lu.se.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Child
Core Binding Factor Alpha 2 Subunit / genetics
Humans
Interleukin-1 Receptor Accessory Protein
Oncogene Proteins, Fusion / genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics

Substances

Core Binding Factor Alpha 2 Subunit
Oncogene Proteins, Fusion
RUNX1 protein, human
IL1RAP protein, human
Interleukin-1 Receptor Accessory Protein

Grants and funding

Funding: This work was supported by the Swedish Children’s Cancer Foundation, the Swedish Cancer Society, the Swedish Research Council, the Knut and Alice Wallenberg Foundation, the Magnus Bergvall Foundation, the Royal Physiographic Society, the Medical Faculty of Lund University, and Region Skåne (ALF-medel).