Drebrin promotes lung adenocarcinoma cell migration through inducing integrin β1 endocytosis

Qiaoyan Yu; Feiyu Tang; Fuyang Cao; Xiyan Tan; Liang Weng; Lunquan Sun

doi:10.1016/j.bbrc.2022.09.050

Drebrin promotes lung adenocarcinoma cell migration through inducing integrin β1 endocytosis

Biochem Biophys Res Commun. 2022 Nov 19:630:175-182. doi: 10.1016/j.bbrc.2022.09.050. Epub 2022 Sep 15.

Authors

Qiaoyan Yu¹, Feiyu Tang², Fuyang Cao², Xiyan Tan², Liang Weng³, Lunquan Sun⁴

Affiliations

¹ Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
² Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China.
³ Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China; Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer, Changsha, 410008, China; Hunan Provincial Clinical Research Center for Respiratory Diseases, Changsha, China; Center for Molecular Imaging of Central South University, Xiangya Hospital, Changsha, 410008, China.
⁴ Department of Oncology, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, 410008, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha, 410008, China; Hunan International Science and Technology Collaboration Base of Precision Medicine for Cancer, Changsha, 410008, China; Center for Molecular Imaging of Central South University, Xiangya Hospital, Changsha, 410008, China. Electronic address: lunquansun@csu.edu.cn.

PMID: 36155064
DOI: 10.1016/j.bbrc.2022.09.050

Abstract

Lung adenocarcinoma (LUAD) is the most common type of lung cancers, which remains the leading cause of cancer-related death worldwide. Drebrin can promote cell migration and invasion with poor prognosis, but its roes in LUAD tumor progression remains unknown. We showed that the expression of Drebrin was upregulated in clinical LUAD samples. A Kaplan-Meier survival analysis showed that a high expression of Drebrin predicated poor prognosis in LUAD. In vitro, Drebrin promoted anchorage-independent growth and migration of LUAD cells. Drebrin interacted with dynamin through CT domain, and served as an adaptor to promote LUAD cell migration through inducing integrin β1 endocytosis. Thus, this study demonstrated the critical role of Drebrin in LUAD and associated mechanism.

Keywords: Drebrin; Integrin β1 endocytosis; Lung adenocarcinoma; Migration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma of Lung* / pathology
Cell Line, Tumor
Cell Movement
Cell Proliferation
Endocytosis
Gene Expression Regulation, Neoplastic
Humans
Integrin beta1 / genetics
Integrin beta1 / metabolism
Lung Neoplasms* / pathology
Neuropeptides* / genetics

Substances

Integrin beta1
Neuropeptides
drebrins