Analyzing the impact of CFP1 mutational landscape on epigenetic signaling

Yidai Yang; Yaqing Yang; Kin Chan; Jean-Francois Couture

doi:10.1096/fj.202100427R

Analyzing the impact of CFP1 mutational landscape on epigenetic signaling

FASEB J. 2021 Aug;35(8):e21790. doi: 10.1096/fj.202100427R.

Authors

Yidai Yang^{1

2

3}, Yaqing Yang^{1

3}, Kin Chan^{1

3}, Jean-Francois Couture^{1

2

3}

Affiliations

¹ Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.
² Shanghai Institute of Materia Medica-University of Ottawa Research Center in Systems and Personalized Pharmacology, University of Ottawa, Ottawa, ON, Canada.
³ Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

PMID: 34320252
DOI: 10.1096/fj.202100427R

Abstract

CXXC Zinc finger protein 1 (CFP1) is a multitasking protein playing essential roles during various developmental processes. Its ability to interact with several proteins contribute to several epigenetic events. Here, we review CFP1's functions and its impact on DNA methylation and the post-translational modification of histone proteins such as lysine acetylation and methylation. We will also discuss the potential role of CFP1 in carcinogenesis and the impact of the mutations identified in patients suffering from various cancers.

Keywords: CFP1; cancer; epigenetics.

Publication types

Review

MeSH terms

Animals
Epigenesis, Genetic*
Gene Expression Regulation, Neoplastic
Humans
Mutation*
Neoplasms / metabolism*
Trans-Activators / genetics
Trans-Activators / metabolism*

Substances

CXXC1 protein, human
Trans-Activators