MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury

Junni Wang; Wanyun Nie; Xishao Xie; Mengqiu Bai; Yanhong Ma; Lini Jin; Liang Xiao; Peng Shi; Yi Yang; Pedro A Jose; Ines Armando; Jianghua Chen; Weiqiang Lin; Fei Han

doi:10.1161/HYPERTENSIONAHA.120.16900

MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury

Hypertension. 2021 May 5;77(5):1613-1626. doi: 10.1161/HYPERTENSIONAHA.120.16900. Epub 2021 Mar 29.

Authors

Junni Wang^#^{1

2

3}, Wanyun Nie^#^{1

2

3}, Xishao Xie^#^{1

2

3}, Mengqiu Bai^{1

4

2

3}, Yanhong Ma^{1

2

3}, Lini Jin^{1

2

3}, Liang Xiao^{1

2

3}, Peng Shi⁴, Yi Yang^{1

2

3}, Pedro A Jose⁵, Ines Armando⁵, Jianghua Chen^{1

2

3}, Weiqiang Lin^{1

4

2

3}, Fei Han^{1

2

3}

Affiliations

¹ Kidney Disease Center, The First Affiliated Hospital (J.W., W.N., X.X., M.B., Y.M., L.J., L.X., Y.Y., J.C., W.L., F.H.).
² Institute of Nephrology, Zhejiang University, Hangzhou, China (J.W., W.N., X.X., M.B., Y.M., L.J., L.X., Y.Y., J.C., W.L., F.H.).
³ Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province, Hangzhou, China (J.W., W.N., X.X., M.B., Y.M., L.J., L.X., Y.Y., J.C., W.L., F.H.).
⁴ Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China (M.B., P.S., W.L.).
⁵ Department of Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC (P.A.J., I.A.).

^# Contributed equally.

PMID: 33775119
DOI: 10.1161/HYPERTENSIONAHA.120.16900

Abstract

[Figure: see text].

Keywords: fibrosis; inflammation; kidney; macrophage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ADAM Proteins / genetics
ADAM Proteins / metabolism*
Acute Kidney Injury / genetics
Acute Kidney Injury / metabolism*
Acute Kidney Injury / pathology
Animals
Cell Line
Chemokine CCL2 / genetics
Chemokine CCL2 / metabolism
Disease Models, Animal
Fibrosis / genetics
Fibrosis / metabolism
Fibrosis / pathology
Humans
Kidney / metabolism*
Kidney / pathology
Macrophage Activation / physiology*
Male
Mice
MicroRNAs / genetics
MicroRNAs / metabolism*
Rats

Substances

Chemokine CCL2
MIRN874 microRNA, mouse
MicroRNAs
ADAM Proteins
Adam19 protein, mouse