Relationship of Platelet Glycoprotein IIb/IIIa and CD62P With Hypercoagulable State After Oncologic Surgery

Clin Appl Thromb Hemost. 2020 Jan-Dec:26:1076029620977906. doi: 10.1177/1076029620977906.

Abstract

The biomarkers for predicting venous thromboembolic events (VTEs) after oncologic surgery are still lacking. The current study aimed to analyze the relationships of CD62P and GP IIb/IIIa with hypercoagulation after oncologic surgery. A total of 76 patients with primary abdominopelvic tumors in our hospital were enrolled. The patients were divided into groups A (malignancy with no VTE group), B (malignancy with VTE group), and C (benign with no VTE group). Twenty healthy volunteers were selected as control. The plasma CD62P (4.69 ± 2.55 vs. 1.76 ± 0.48) and the GP IIb/IIIa (9.28 ± 3.79 vs. 1.76 ± 0.48) levels in group A were significantly higher than those in the control group preoperatively. The CD62P (31.46 ± 17.13 vs. 13.51 ± 7.43, P < 0.05), GP IIb/IIIa (42.33 ± 21.82 vs. 13.51 ± 7.43, P < 0.05), and D-dimer (7.33 ± 2.34 vs. 2.03 ± 0.55, P < 0.05) levels in group B were markedly higher 7 days after operation compared with those in group A. The CD62P and the GP IIb/IIIa exhibited a positive correlation with the hypercoagulable state after oncologic surgery.

Keywords: CD62P; GP IIb/IIIa; biomarker; oncologic surgery; venous thromboembolism.

MeSH terms

  • Adult
  • Aged
  • Blood Coagulation
  • Blood Platelets / pathology
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / blood*
  • Neoplasms / complications
  • Neoplasms / pathology
  • Neoplasms / surgery*
  • P-Selectin / blood*
  • Platelet Glycoprotein GPIIb-IIIa Complex / analysis*
  • Thrombophilia / blood*
  • Thrombophilia / etiology
  • Thrombophilia / pathology
  • Venous Thromboembolism / blood*
  • Venous Thromboembolism / etiology
  • Venous Thromboembolism / pathology

Substances

  • Fibrin Fibrinogen Degradation Products
  • P-Selectin
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • SELP protein, human
  • fibrin fragment D