A Pathogenic Variant in ALPK3 Is Associated With an Autosomal Dominant Adult-onset Hypertrophic Cardiomyopathy

Circ Genom Precis Med. 2020 Dec;13(6):e003127. doi: 10.1161/CIRCGEN.120.003127. Epub 2020 Nov 15.

Chanatjit Cheawsamoot^{1

2

3}, Chureerat Phokaew^{1

3}, Wanna Chetruengchai^{1

3}, Poonchavist Chantranuwat⁴, Sarinya Puwanant⁵, Sissades Tongsima^{6

7}, Apichai Khongphatthanayothin^{8

9}, Vorasuk Shotelersuk^{1

3}

¹ Center of Excellence for Medical Genomics, Medical Genomics Cluster, Department of Pediatrics, Faculty of Medicine (C.C., C.P., W.C., V.S.).
² Interdepartment Program of Biomedical Sciences, Faculty of Graduate School (C.C.).
³ Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society (C.C., C.P., W.C., V.S.).
⁴ Department of Pathology, Faculty of Medicine (P.C.).
⁵ Division of Cardiology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok (S.P.).
⁶ National Center for Genetic Engineering & Biotechnology, National Science & Technology Development Agency (S.T.).
⁷ National Biobank of Thailand, National Science & Technology Development Agency, Pathum Thani (S.T.).
⁸ Division of Cardiology, Department of Pediatrics and Center of Excellence in Arrhythmia Research, Department of Medicine, Faculty of Medicine, Chulalongkorn University (A.K.).
⁹ Bangkok General Hospital, Thailand(A.K.).

No abstract available

Keywords: atrial fibrillation; cardiomyopathy, hypertrophic; genetics; heart failure; whole genome sequencing.

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