ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma

Biomark Med. 2020 Oct;14(15):1415-1426. doi: 10.2217/bmm-2020-0432. Epub 2020 Sep 7.

Abstract

Background: We investigated whether ADAMTS9-AS2 and CADM2 were related to esophageal squamous cell carcinoma (ESCC). Methodology: ESCC microarray datasets and reverse transcriptase qualitative PCR were used to analyze ADAMTS9-AS2 and CADM2 expression. Results: The GSE120356 and GSE33810 datasets identified ADAMTS9-AS2 and CADM2 as the candidates and ADAMTS9-AS2 and CADM2 expression was downregulated in ESCC. ADAMTS9-AS2 and CADM2 were positively correlated with ESCC. ADAMTS9-AS2 and CADM2 expression could discriminate ESCC from normal tissue. Five-year overall survival was shorter in underexpressed ADAMTS9-AS2 patients, and CADM2 expression level was related to 5-year overall survival. ADAMTS9-AS2 and CADM2 expression were independent prognosis indicators in ESCC patients. Conclusion: Our findings shed new light on the clinical significance of ADAMTS9-AS2 and CADM2 in ESCC carcinogenesis.

Keywords: ADAMTS9-AS2; CADM2; esophageal squamous cell carcinoma; overall survival; prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADAMTS9 Protein / genetics
  • ADAMTS9 Protein / metabolism
  • Adult
  • Aged
  • Aged, 80 and over
  • Apoptosis / genetics
  • Cell Adhesion Molecules / genetics*
  • Cell Adhesion Molecules / metabolism
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • China
  • Databases, Genetic
  • Esophageal Neoplasms / pathology
  • Esophageal Squamous Cell Carcinoma / genetics*
  • Esophageal Squamous Cell Carcinoma / metabolism
  • Female
  • Gene Expression / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Head and Neck Neoplasms / genetics
  • Humans
  • Male
  • MicroRNAs / genetics
  • Middle Aged
  • Prognosis
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • Signal Transduction / genetics
  • Squamous Cell Carcinoma of Head and Neck / genetics
  • Transcriptome / genetics

Substances

  • CADM2 protein, human
  • Cell Adhesion Molecules
  • MicroRNAs
  • RNA, Long Noncoding
  • lncRNA ADAMTS9-AS2, human
  • ADAMTS9 Protein
  • ADAMTS9 protein, human