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Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.
Sci Immunol. 2020 Jan 17;5(43):eaax7969. doi: 10.1126/sciimmunol.aax7969.
Sci Immunol. 2020.
PMID: 31953257
Clinical Trial.
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J.
Zhang Z, et al.
Nature. 2020 Mar;579(7799):415-420. doi: 10.1038/s41586-020-2071-9. Epub 2020 Mar 11.
Nature. 2020.
PMID: 32188940
Free PMC article.
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