Introduction: Preeclampsia has the highest rate of obstetric morbidity and mortality.
Methods: We recruited 21 women with preeclampsia and 27 women with uncomplicated pregnancies. We used a quantitative protein macroarray that allowed for analysis of 40 proteins.
Results: We found a statistically significant increase in the concentration of DR3, LIF and a significant decrease of VEGF, PlGF, syndecan-4 and galectin-2, in the plasma of women with preeclampsia.
Conclusions: There are no previous studies assessing syndecan 4, galectin 2, and DR3 concentrations in women with preeclampsia; Our results indicate these proteins are new factors that play important roles in the immunological pathomechanism of preeclampsia.
Keywords: Angiogenesis; apoptosis; cytokine; immune response; inflammatory factors; placenta; preeclampsia.