Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development

Nat Commun. 2019 Sep 20;10(1):4297. doi: 10.1038/s41467-019-12325-z.

Abstract

Tet-mediated DNA demethylation plays an important role in shaping the epigenetic landscape and chromatin accessibility to control gene expression. While several studies demonstrated pivotal roles of Tet in regulating embryonic development, little is known about their functions in heart development. Here we analyze DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice. We find that cardiac-specific deletion of Tet2 and Tet3 in mice (Tet2/3-DKO) leads to ventricular non-compaction cardiomyopathy (NCC) with embryonic lethality. Single-cell RNA-seq analyses reveal a reduction in cardiomyocyte numbers and transcriptional reprogramming in cardiac tissues upon Tet2/3 depletion. Impaired DNA demethylation and reduced chromatin accessibility in Tet2/3-DKO mice further compromised Ying-yang1 (YY1) binding to its genomic targets, and perturbed high-order chromatin organization at key genes involved in heart development. Our studies provide evidence of the physiological role of Tet in regulating DNA methylation dynamics and chromatin organization during early heart development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiomyopathies / genetics
  • Cardiomyopathies / metabolism
  • Catalytic Domain
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Chromatin / metabolism*
  • DNA Demethylation
  • DNA Methylation
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Dioxygenases
  • Embryonic Development / genetics
  • Embryonic Development / physiology*
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Heart / embryology
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocytes, Cardiac / metabolism
  • Organogenesis / genetics
  • Organogenesis / physiology*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • YY1 Transcription Factor / metabolism*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • YY1 Transcription Factor
  • Yy1 protein, mouse
  • Dioxygenases
  • Tet2 protein, mouse
  • Tet3 protein, mouse