BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection

Front Immunol. 2019 Mar 29:10:617. doi: 10.3389/fimmu.2019.00617. eCollection 2019.

Abstract

B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV infection.

Keywords: B and T lymphocyte attenuator; T lymphocyte; hepatitis B virus; herpes virus entry mediator; milestones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hepatitis B virus / immunology*
  • Hepatitis B, Chronic / immunology*
  • Humans
  • Immune Tolerance*
  • Receptors, Immunologic / immunology*
  • Receptors, Tumor Necrosis Factor, Member 14 / immunology*
  • Signal Transduction / immunology*

Substances

  • BTLA protein, human
  • Receptors, Immunologic
  • Receptors, Tumor Necrosis Factor, Member 14
  • TNFRSF14 protein, human