Comparison of the clinical performance of upper abdominal PET/DCE-MRI with and without concurrent respiratory motion correction (MoCo)

Onofrio A Catalano; Lale Umutlu; Niccolo Fuin; Matthew Louis Hibert; Michele Scipioni; Stefano Pedemonte; Mark Vangel; Andreea Maria Catana; Ken Herrmann; Felix Nensa; David Groshar; Umar Mahmood; Bruce R Rosen; Ciprian Catana

doi:10.1007/s00259-018-4084-2

Comparison of the clinical performance of upper abdominal PET/DCE-MRI with and without concurrent respiratory motion correction (MoCo)

Eur J Nucl Med Mol Imaging. 2018 Nov;45(12):2147-2154. doi: 10.1007/s00259-018-4084-2. Epub 2018 Jul 11.

Authors

Onofrio A Catalano^{1

2}, Lale Umutlu³, Niccolo Fuin⁴, Matthew Louis Hibert⁴, Michele Scipioni⁵, Stefano Pedemonte⁴, Mark Vangel⁶, Andreea Maria Catana⁷, Ken Herrmann⁸, Felix Nensa³, David Groshar⁹, Umar Mahmood⁴, Bruce R Rosen⁴, Ciprian Catana⁴

Affiliations

¹ Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th St., Charlestown, MA, 02129, USA. onofriocatalano@yahoo.it.
² University of Naples "Parthenope", Naples, Italy. onofriocatalano@yahoo.it.
³ Department of Radiology, Universitat Duisburg-Essen, Essen, Germany.
⁴ Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th St., Charlestown, MA, 02129, USA.
⁵ Department of Information Engineering, University of Pisa, Pisa, Italy.
⁶ Department of Biostatistics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁷ Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
⁸ Department of Nuclear Medicine, Universitat Duisburg-Essen, Essen, Germany.
⁹ Assuta Medical Center and Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

PMID: 29998420
DOI: 10.1007/s00259-018-4084-2

Abstract

Purpose: To compare the clinical performance of upper abdominal PET/DCE-MRI with and without concurrent respiratory motion correction (MoCo).

Methods: MoCo PET/DCE-MRI of the upper abdomen was acquired in 44 consecutive oncologic patients and compared with non-MoCo PET/MRI. SUVmax and MTV of FDG-avid upper abdominal malignant lesions were assessed on MoCo and non-MoCo PET images. Image quality was compared between MoCo DCE-MRI and non-MoCo CE-MRI, and between fused MoCo PET/MRI and fused non-MoCo PET/MRI images.

Results: MoCo PET resulted in higher SUVmax (10.8 ± 5.45) than non-MoCo PET (9.62 ± 5.42) and lower MTV (35.55 ± 141.95 cm³) than non-MoCo PET (38.11 ± 198.14 cm³; p < 0.005 for both). The quality of MoCo DCE-MRI images (4.73 ± 0.5) was higher than that of non-MoCo CE-MRI images (4.53±0.71; p = 0.037). The quality of fused MoCo-PET/MRI images (4.96 ± 0.16) was higher than that of fused non-MoCo PET/MRI images (4.39 ± 0.66; p < 0.005).

Conclusion: MoCo PET/MRI provided qualitatively better images than non-MoCo PET/MRI, and upper abdominal malignant lesions demonstrated higher SUVmax and lower MTV on MoCo PET/MRI.

Keywords: Abdomen; Oncology; PET/MRI; Respiratory motion correction.

Publication types

Comparative Study

MeSH terms

Abdomen / diagnostic imaging
Abdominal Neoplasms / diagnostic imaging*
Adult
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Motion
Multimodal Imaging / methods*
Positron-Emission Tomography / methods*
Respiratory-Gated Imaging Techniques / methods*