Abstract
It is now accepted that vitamin D is an integral part of a complex endocrine system, one with far-reaching implications in mineral metabolism. Reviews of the sources, functions and metabolism of vitamin D, as currently understood, are presented as a prelude to discussions of the role of vitamin D in calcium and phosphorous homeostatis and possible specific roles for vitamin D in mineralized tissues. Data describing a possible regulatory function for vitamin D in bone and bone protein metabolism are presented. Some of the controversy which presently exists regarding the biochemical mechanism of the action of this vitamin is discussed. Finally, the possible relationship of vitamin D and disorders of skeletal tissues is described.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bone Resorption / drug effects
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Bone and Bones / metabolism*
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Calcium / metabolism
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Cell Nucleus / metabolism
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Chemical Phenomena
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Chemistry
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Cholecalciferol / metabolism
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Chronic Kidney Disease-Mineral and Bone Disorder / complications
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Chronic Kidney Disease-Mineral and Bone Disorder / drug therapy
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Glucocorticoids / adverse effects
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Humans
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Hydroxylation
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Intestinal Mucosa / metabolism
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Kidney / metabolism
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Osteogenesis
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Osteoporosis / drug therapy
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Parathyroid Hormone / metabolism
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Proteins / metabolism
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Rats
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Vitamin D / analogs & derivatives
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Vitamin D / metabolism
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Vitamin D / physiology*
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Vitamin D Deficiency / metabolism
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Vitamin D-Binding Protein / metabolism
Substances
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Glucocorticoids
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Parathyroid Hormone
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Proteins
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Vitamin D-Binding Protein
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Vitamin D
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Cholecalciferol
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Calcium