Objective To study the single nucleotide polymorphisms (SNPs)that predict a patient's risk of grade 2-3 paclitaxel-induced peripheral sensory neuropathy (PSN) in Chinese Han populations.Methods Totally 216 patients received paclitaxel in Peking Union Medical College Hospital from May 2014 to December 2016 were enrolled.DNA was isolated from peripheral blood.Genotyping for eight candidate SNPs was performed on Sequenom-MassARRARYiPLEX platform.Patients were followed up and PSN was assessed by trained physicians according to National Cancer Institute-Common Terminology Criteria for Adverse Events v4.03.Results A total of 209 patients entered the final analysis.Among the candidate SNPs,only rs4141404:A>C(LIMK2) was significantly associated with grade 2/3 PSN (OR:4.32,95%CI:2.37-7.89,P<0.0001).In multivariate logistic regression analysis,both rs4141404:A>C(LIMK2) and history of receiving platinum compound (OR:2.70,95%CI:1.32-5.51,P=0.007) were associated with grade 2/3 PSN.Conclusion rs4141404:A>C(LIMK2) may be the markers of risk of grade 2/3 PSN.
目的 在中国汉族人群中研究与2/3级紫杉醇介导的外周感觉神经病变(PSN)相关的单核苷酸基因多态性(SNP)位点及临床特点。方法 以2014年5月至2016年12月在北京协和医院接受紫杉醇方案化疗的216例患者为研究对象,提取外周血DNA,选取8个候选SNP位点,采用Sequenom-MassARRARYiPLEX平台测定基因型。依据美国国家癌症研究院-不良反应常见术语评定标准,由受训的临床医生完成患者随访及PSN分级。结果 共有209例患者最终纳入分析。在候选SNP位点中,仅rs4141404:A>C(LIMK2)与2/3级PSN显著相关(OR:4.32,95%CI:2.37~7.89,P<0.0001)。多因素Logistic 回归分析结果显示,rs4141404:A>C(LIMK2)多态性及既往使用铂类制剂(OR:2.70,95%CI:1.32~5.51,P=0.007)与2/3级PSN发生风险相关。结论 rs4141404:A>C(LIMK2)多态性可能是中国汉族人群发生紫杉醇介导的2/3级PSN的风险因素。