Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes

Ju Hee Lee; Yea Eun Kang; Ji Min Kim; Sorim Choung; Kyong Hye Joung; Hyun Jin Kim; Bon Jeong Ku

doi:10.1016/j.diabres.2017.10.005

Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes

Diabetes Res Clin Pract. 2018 Jan:135:7-10. doi: 10.1016/j.diabres.2017.10.005. Epub 2017 Oct 31.

Authors

Ju Hee Lee¹, Yea Eun Kang¹, Ji Min Kim¹, Sorim Choung², Kyong Hye Joung¹, Hyun Jin Kim¹, Bon Jeong Ku³

Affiliations

¹ Department of Internal Medicine, Chungnam National University School of Medicine, 266 Munwha-ro, Jung-gu, Daejeon 35015, Republic of Korea.
² Department of Medical Science, Chungnam National University School of Medicine, 266 Munwha-ro, Jung-gu, Daejeon 35015, Republic of Korea.
³ Department of Internal Medicine, Chungnam National University School of Medicine, 266 Munwha-ro, Jung-gu, Daejeon 35015, Republic of Korea. Electronic address: bonjeong@cnu.ac.kr.

PMID: 29097285
DOI: 10.1016/j.diabres.2017.10.005

Abstract

We analyzed circulating Meteorin-like (METRNL) levels in human. Serum METRNL levels were significantly lower in subjects with diabetes mellitus compared with those without diabetes. Serum METRNL was negatively correlated with the serum glucose level and insulin resistance. Metformin treatment did not increase the serum METRL levels after 12 weeks.

Keywords: Diabetes mellitus; Insulin resistance; Meteorin-like.

MeSH terms

Diabetes Mellitus, Type 2 / blood*
Diabetes Mellitus, Type 2 / diagnosis
Female
Humans
Insulin / blood*
Insulin Resistance / physiology*
Intercellular Signaling Peptides and Proteins / blood*
Male
Metformin / therapeutic use
Middle Aged
Nerve Tissue Proteins / blood*

Substances

Insulin
Intercellular Signaling Peptides and Proteins
METRN protein, human
Nerve Tissue Proteins
Metformin