Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs

Arch Toxicol Suppl. 1979:(2):393-6. doi: 10.1007/978-3-642-67265-1_44.

Abstract

Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles. Best therapeutic efficiency was shown by HGG-42 in a dosage of 30 muMol/kg. Also good effects were produced by the combination of both oximes in a low dosage of 3 muMol/kg for each one. In soman poisoning no significant reactivation of cholinesterase in serum or erythrocytes was observed.

MeSH terms

  • Animals
  • Antidotes*
  • Aspartate Aminotransferases / blood
  • Atropine / therapeutic use*
  • Benactyzine / therapeutic use*
  • Cholinesterase Inhibitors / poisoning*
  • Cholinesterases / blood
  • Creatine Kinase / blood
  • Dogs
  • Lethal Dose 50
  • Male
  • Organothiophosphorus Compounds / poisoning*
  • Pyridinium Compounds / therapeutic use*
  • Sarin / poisoning
  • Soman / poisoning

Substances

  • Antidotes
  • Cholinesterase Inhibitors
  • Organothiophosphorus Compounds
  • Pyridinium Compounds
  • Benactyzine
  • Atropine
  • Soman
  • Sarin
  • Aspartate Aminotransferases
  • Creatine Kinase
  • Cholinesterases