Abstract
Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles. Best therapeutic efficiency was shown by HGG-42 in a dosage of 30 muMol/kg. Also good effects were produced by the combination of both oximes in a low dosage of 3 muMol/kg for each one. In soman poisoning no significant reactivation of cholinesterase in serum or erythrocytes was observed.
MeSH terms
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Animals
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Antidotes*
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Aspartate Aminotransferases / blood
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Atropine / therapeutic use*
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Benactyzine / therapeutic use*
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Cholinesterase Inhibitors / poisoning*
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Cholinesterases / blood
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Creatine Kinase / blood
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Dogs
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Lethal Dose 50
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Male
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Organothiophosphorus Compounds / poisoning*
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Pyridinium Compounds / therapeutic use*
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Sarin / poisoning
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Soman / poisoning
Substances
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Antidotes
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Cholinesterase Inhibitors
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Organothiophosphorus Compounds
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Pyridinium Compounds
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Benactyzine
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Atropine
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Soman
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Sarin
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Aspartate Aminotransferases
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Creatine Kinase
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Cholinesterases