Alpha-tocopherol: uses in preventing nitrosamine formation

IARC Sci Publ (1971). 1978:(19):199-212.

Abstract

alpha-Tocopherol has been evaluated as a nitrite scavenger for the prevention of nitrosamine formation in a model system and under practical conditions. alpha-Tocopherol was found to react with nitrosating agents in both lipophilic and aqueous environments. The use of alpha-tocopherol was shown to inhibit aminopyrene-nitrite induced hepatotoxicity in rats and to reduce the amount of NDMA formed in cigarette smoke. Of primary interest is the finding of a significant reduction of NPYR formation in fried bacon. Nitrosamine inhibition was greater with alpha-tocopherol used in combination with sodium ascorbate than with sodium ascorbate alone.

MeSH terms

  • Animals
  • Ascorbic Acid
  • Chemical Phenomena
  • Chemistry
  • Hydrogen-Ion Concentration
  • Meat / analysis
  • Nitrites
  • Nitrosamines / analysis
  • Nitrosamines / metabolism*
  • Rats
  • Smoking / metabolism
  • Swine
  • Vitamin E / pharmacology*

Substances

  • Nitrites
  • Nitrosamines
  • Vitamin E
  • Ascorbic Acid