Association between interleukin-19 and angiopoietin-2 with vascular complications in type 2 diabetes

J Diabetes Investig. 2016 Nov;7(6):895-900. doi: 10.1111/jdi.12519. Epub 2016 Apr 24.

Abstract

Aims/introduction: The aim of the present study was to investigate the role of interleukin-19 (IL-19) in angiogenesis of type 2 diabetes mellitus with complications, and to assess the relationship of serum IL-19 and angiopoietin-2 (Ang-2) in type 2 diabetes mellitus.

Materials and methods: The group studied comprised of 240 patients with type 2 diabetes mellitus (132 men and 108 women), and included macrovascular complications, microvascular complications and type 2 diabetes mellitus without vascular complications. The control group consisted of 50 healthy blood donors. All participants were evaluated for: IL-19, Ang-2, fasting plasma glucose, fasting insulin and glycosylated hemoglobin.

Results: The serum IL-19 levels of type 2 diabetes mellitus patients with angiopathy were found to be significantly higher compared with patients without angiopathy. IL-19 levels were significantly positively correlated with Ang-2, homeostasis model assessment for insulin resistance and glycosylated hemoglobin (r = 0.769, 0.523 and 0.491, respectively, P < 0.01). In multivariable logistic regression analysis, IL-19 levels (P = 0.01) were found to be independently associated with patients with type 2 diabetes mellitus complications.

Conclusions: These data are the first to implicate the association between the IL-19 and type 2 diabetes mellitus with vascular complications. IL-19 is significantly positively correlated with Ang-2. The potential role of IL-19 and Ang-2 in the pathogenesis of vascular complications in type 2 diabetes could warrant further study.

Keywords: Angiopoietin-2; Interleukin-19; Vascular complications.

MeSH terms

  • Aged
  • Angiopoietin-2 / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Glycated Hemoglobin / analysis
  • Humans
  • Interleukins / blood*
  • Male
  • Middle Aged
  • Neovascularization, Pathologic / complications*

Substances

  • ANGPT2 protein, human
  • Angiopoietin-2
  • Glycated Hemoglobin A
  • IL19 protein, human
  • Interleukins
  • hemoglobin A1c protein, human