GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations

Blood. 2015 Oct 8;126(15):1865-7. doi: 10.1182/blood-2015-07-661264. Epub 2015 Aug 31.

Authors

Maksim Klimiankou¹, Olga Klimenkova¹, Murat Uenalan², Alexander Zeidler³, Sabine Mellor-Heineke³, Siarhei Kandabarau³, Julia Skokowa¹, Cornelia Zeidler³, Karl Welte⁴

Affiliations

¹ Department of Hematology, Oncology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
² Department of Experimental Hematology, Hannover Medical School, Hannover, Germany.
³ Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany.
⁴ Department of Pediatrics, University Hospital Tuebingen, Tuebingen, Germany.

PMID: 26324699
DOI: 10.1182/blood-2015-07-661264

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use*
Granulocytes / cytology*
Granulocytes / drug effects
Heterozygote
Humans
Infant, Newborn
Loss of Heterozygosity*
Mutation / genetics*
Neutropenia / congenital*
Neutropenia / drug therapy
Neutropenia / genetics*
Prognosis
Receptors, Colony-Stimulating Factor / genetics*

Substances

CSF3R protein, human
Receptors, Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor