Abstract
Different colouring matters with high molar extinction coefficient were tested at the Friedrich Schiller University with regard to their photodynamic efficacy. Test system was the rapid-growing solid Ehrlich carcinoma. Methylen-blue, hematoporphyrin derivative Halle and chlorophyllin produce a markedly reduction of the tumor weight. In the presence of hypoxic areas an additional application of nitroimidazols is possible. A pilot laser unit for photochemotherapy of urinary bladder tumors is presented.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Carcinoma, Ehrlich Tumor / drug therapy*
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Carcinoma, Ehrlich Tumor / pathology
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Cell Hypoxia / drug effects
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Cell Survival / drug effects
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Female
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Hematoporphyrin Photoradiation / methods*
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Mice
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Mice, Inbred ICR
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Neoplasm Transplantation
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Neoplasms, Multiple Primary / drug therapy*
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Neoplasms, Multiple Primary / pathology
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Photochemotherapy / methods*
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Urinary Bladder / pathology
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Urinary Bladder Neoplasms / drug therapy*
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Urinary Bladder Neoplasms / pathology