Genetic factors adaptive in a malarial environment may increase the risk of type 1 diabetes

J Diabetes. 2015 May;7(3):430-2. doi: 10.1111/1753-0407.12250. Epub 2015 Feb 19.

Authors

Fulvia Gloria-Bottini¹, Egidio Bottini

Affiliation

¹ Department of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.

PMID: 25492086
DOI: 10.1111/1753-0407.12250

No abstract available

Keywords: P53 codon 72; adenosine deaminase; malaria; type 1 diabetes.

Publication types

Comparative Study

MeSH terms

Adaptation, Physiological / genetics*
Adaptor Proteins, Signal Transducing / genetics*
Case-Control Studies
Child
DNA-Binding Proteins
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / etiology*
Genetic Predisposition to Disease*
Genotype
Humans
Infant, Newborn
Italy / epidemiology
Malaria / epidemiology
Malaria / genetics*
Polymorphism, Single Nucleotide / genetics*
Transcription Factors / genetics*
Tumor Suppressor Protein p53 / genetics*

Substances

Adaptor Proteins, Signal Transducing
DNA-Binding Proteins
TADA2A protein, human
TP53 protein, human
Transcription Factors
Tumor Suppressor Protein p53