The protein p17 signaling pathways in cancer

Tumour Biol. 2013 Dec;34(6):4081-7. doi: 10.1007/s13277-013-0999-1. Epub 2013 Jul 31.

Abstract

P17 is a novel neuronal protein expressed under physiological conditions only at very low levels in other tissues. Accumulating data indicate its crucial involvement in tumorigenic effects. Using molecular, cellular, and biocomputational methods, the current study unraveled p17 mode of action. Data indicate that mitochondria-associated p17 interacts with the proteins TMEM115, YPEL3, ERP44, CDK5RAP, and NNAT. Moreover, p17 drives the cell cycle into the G0/G1 phase and enhances survival of proliferating cells. Interference with p17 activities thus might become a novel option to influence also the tumor suppressor protein p53 signaling pathways for the treatment of tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis Regulatory Proteins / genetics
  • Apoptosis Regulatory Proteins / metabolism*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Line
  • Cell Survival / genetics
  • Cell Survival / physiology
  • G1 Phase / genetics
  • G1 Phase / physiology
  • HEK293 Cells
  • Humans
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • MCF-7 Cells
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Microscopy, Fluorescence
  • Mitochondria / metabolism*
  • Molecular Chaperones / genetics
  • Molecular Chaperones / metabolism
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Protein Binding
  • Resting Phase, Cell Cycle / genetics
  • Resting Phase, Cell Cycle / physiology
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / metabolism
  • Two-Hybrid System Techniques

Substances

  • Apoptosis Regulatory Proteins
  • Carrier Proteins
  • ERP44 protein, human
  • FAM72A protein, human
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Molecular Chaperones
  • NNAT protein, human
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • TMEM115 protein, human
  • Tumor Suppressor Proteins
  • YPEL3 protein, human
  • p17 amyloid-beta peptide-induced protein, human
  • CDK5RAP1 protein, human