Abstract
The effects of maslinic acid (1), a pentacyclic triterpenoid obtained from Olea europaea, were studied in several tests for nociception in mice. Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia. However, it did not induce motor incoordination in the rotarod test. The topical administration of 1 also reduced the inflammatory phase of the formalin test, indicating that at least some of its effects are mediated peripherally. The present results demonstrate for the first time that maslinic acid induces antinociceptive and antiallodynic effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemistry
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Analgesics / isolation & purification*
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Analgesics / pharmacology*
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Animals
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Capsaicin / therapeutic use
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Hyperalgesia / chemically induced
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Hyperalgesia / drug therapy
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Inflammation / chemically induced
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Inflammation / drug therapy
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Mice
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Molecular Structure
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Olea / chemistry*
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Pain / chemically induced
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Pain / drug therapy
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Pain Measurement
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Pregabalin
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Rotarod Performance Test
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Time Factors
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
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gamma-Aminobutyric Acid / analogs & derivatives
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gamma-Aminobutyric Acid / pharmacology
Substances
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Analgesics
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Triterpenes
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Pregabalin
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gamma-Aminobutyric Acid
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maslinic acid
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Capsaicin