Abstract
In order to determine the relationship between expression of cyclic nucleotide phosphodiesterase isoform 7B (PDE7B) and mantle cell lymphoma (MCL) progression, PDE7B mRNA expression was measured by qRT-PCR in 21 untreated MCL patients with bone marrow involvement and 20 healthy donors. The expression level of PDE7B was markedly higher in MCL patients compared with normal controls (P=0.001), and the higher level of PDE7B expression was associated with unfavorable cytogenetic characteristics in MCL. It was showed that higher expression of PDE7B might be a novel unfavorable prognostic indicator in MCL, which possess important clinical significance.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Bone Marrow / enzymology
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Bone Marrow / pathology
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Cyclic Nucleotide Phosphodiesterases, Type 7 / biosynthesis*
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Cyclic Nucleotide Phosphodiesterases, Type 7 / genetics
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Disease-Free Survival
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Female
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Gene Expression Regulation, Enzymologic*
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Gene Expression Regulation, Neoplastic*
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Humans
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Lymphoma, Mantle-Cell / enzymology*
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Lymphoma, Mantle-Cell / genetics
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Lymphoma, Mantle-Cell / mortality*
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Lymphoma, Mantle-Cell / pathology
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Lymphoma, Mantle-Cell / therapy
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Male
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Middle Aged
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Predictive Value of Tests
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RNA, Messenger / biosynthesis*
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RNA, Messenger / genetics
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RNA, Neoplasm / biosynthesis*
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RNA, Neoplasm / genetics
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Retrospective Studies
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Survival Rate
Substances
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Neoplasm Proteins
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RNA, Messenger
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RNA, Neoplasm
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Cyclic Nucleotide Phosphodiesterases, Type 7
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PDE7B protein, human