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Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.
Cell Res. 2013 May;23(5):620-34. doi: 10.1038/cr.2013.16. Epub 2013 Jan 29.
Cell Res. 2013.
PMID: 23357851
Free PMC article.
A proteome-scale map of the human interactome network.
Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Wanamaker SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M.
Rolland T, et al.
Cell. 2014 Nov 20;159(5):1212-1226. doi: 10.1016/j.cell.2014.10.050.
Cell. 2014.
PMID: 25416956
Free PMC article.
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Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.
Guan Y, Huang D, Chen F, Gao C, Tao T, Shi H, Zhao S, Liao Z, Lo LJ, Wang Y, Chen J, Peng J.
Guan Y, et al.
PLoS Biol. 2016 Sep 22;14(9):e1002555. doi: 10.1371/journal.pbio.1002555. eCollection 2016 Sep.
PLoS Biol. 2016.
PMID: 27657329
Free PMC article.
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An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Chen S, Fragoza R, Klei L, Liu Y, Wang J, Roeder K, Devlin B, Yu H.
Chen S, et al.
Nat Genet. 2018 Jul;50(7):1032-1040. doi: 10.1038/s41588-018-0130-z. Epub 2018 Jun 11.
Nat Genet. 2018.
PMID: 29892012
Free PMC article.
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Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD, Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG, Yu H.
Fragoza R, et al.
Nat Commun. 2019 Sep 12;10(1):4141. doi: 10.1038/s41467-019-11959-3.
Nat Commun. 2019.
PMID: 31515488
Free PMC article.
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A reference map of the human binary protein interactome.
Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Coté AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovács IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Taşan M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP, Calderwood MA.
Luck K, et al.
Nature. 2020 Apr;580(7803):402-408. doi: 10.1038/s41586-020-2188-x. Epub 2020 Apr 8.
Nature. 2020.
PMID: 32296183
Free PMC article.
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