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TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation.
J Immunol. 2012 Feb 1;188(3):1098-107. doi: 10.4049/jimmunol.1101121. Epub 2011 Dec 23.
J Immunol. 2012.
PMID: 22198949
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.
Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV.
Deane R, et al.
J Clin Invest. 2012 Apr;122(4):1377-92. doi: 10.1172/JCI58642. Epub 2012 Mar 12.
J Clin Invest. 2012.
PMID: 22406537
Free PMC article.
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Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.
Holland R, McIntosh AL, Finucane OM, Mela V, Rubio-Araiz A, Timmons G, McCarthy SA, Gun'ko YK, Lynch MA.
Holland R, et al.
Brain Behav Immun. 2018 Feb;68:183-196. doi: 10.1016/j.bbi.2017.10.017. Epub 2017 Oct 20.
Brain Behav Immun. 2018.
PMID: 29061364
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