Abstract
In exploring the primary sequence of the human papilloma virus (HPV) 16 major capsid L1 protein for peptide sharing with human proteins, we find that 34 pentamers from the viral capsid protein are shared with human proteins that, when altered, have been linked to short QT syndrome, arrhythmogenic cardiac disorders, cardiovascular diseases and sudden death. In particular, nine out of the 34 viral pentamers are present in a human protein, titin, alterations of which have been linked to cardiac failure and sudden cardiac death. The present data may help evaluate the potential crossreactivity risks in anti-tumor vaccination protocols based on HPV16 L1 protein.
MeSH terms
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Antigens / chemistry*
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Antigens / immunology
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Capsid Proteins / chemistry*
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Capsid Proteins / immunology
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Capsid Proteins / metabolism
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Cardiovascular Diseases / physiopathology
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Connectin
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Cross Reactions / immunology
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Death, Sudden, Cardiac / pathology*
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Humans
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Muscle Proteins / chemistry
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Muscle Proteins / metabolism
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Oncogene Proteins, Viral / chemistry*
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Oncogene Proteins, Viral / immunology
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Oncogene Proteins, Viral / metabolism
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Papillomavirus Vaccines / immunology
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Protein Kinases / chemistry
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Protein Kinases / metabolism
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Proteome / chemistry*
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Sequence Analysis, Protein
Substances
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Antigens
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Capsid Proteins
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Connectin
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Muscle Proteins
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Oncogene Proteins, Viral
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Papillomavirus Vaccines
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Proteome
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TTN protein, human
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L1 protein, Human papillomavirus type 16
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Protein Kinases