A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand-receptor binding

Yong Yang; Yongchun Xu; Tie Xia; Fangjin Chen; Chunling Zhang; Wei Liang; Luhua Lai; Xiaohong Fang

doi:10.1039/c1cc10778j

A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand-receptor binding

Chem Commun (Camb). 2011 May 21;47(19):5440-2. doi: 10.1039/c1cc10778j. Epub 2011 Apr 8.

Authors

Yong Yang¹, Yongchun Xu, Tie Xia, Fangjin Chen, Chunling Zhang, Wei Liang, Luhua Lai, Xiaohong Fang

Affiliation

¹ Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Key Laboratory of Molecular Nanostructures and Nanotechnology, Chinese Academy of Sciences, Beijing 100190, PR China.

PMID: 21475751
DOI: 10.1039/c1cc10778j

Abstract

With single-molecule fluorescence imaging and single-molecule force measurement, we have found that the natural compound Naringenin exerts an inhibition effect on TGF-β ligand-receptor interaction, the initial step of TGF-β signaling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Flavanones / pharmacology*
HeLa Cells
Humans
Ligands
Microscopy, Atomic Force*
Molecular Imaging*
Protein Binding / drug effects
Transforming Growth Factor beta / metabolism*

Substances

Flavanones
Ligands
Transforming Growth Factor beta
naringenin