A new intravenous fat emulsion containing soybean oil, medium-chain triglycerides, olive oil, and fish oil: a single-center, double-blind randomized study on efficacy and safety in pediatric patients receiving home parenteral nutrition

JPEN J Parenter Enteral Nutr. 2010 Sep-Oct;34(5):485-95. doi: 10.1177/0148607110363614.

Abstract

Background: SMOFlipid 20% is an intravenous lipid emulsion (ILE) containing soybean oil, medium-chain triglycerides, olive oil, and fish oil developed to provide energy, essential fatty acids (FAs), and long-chain ω-3 FAs as a mixed emulsion containing α-tocopherol. The aim was to assess the efficacy and safety of this new ILE in pediatric patients receiving home parenteral nutrition (HPN) compared with soybean oil emulsion (SOE).

Methods: This single-center, randomized, double-blind study included 28 children on HPN allocated to receive either SMOFlipid 20% (n = 15) or a standard SOE (Intralipid 20%, n = 13). ILE was administered 4 to 5 times per week (goal dose, 2.0 g/kg/d) within a parenteral nutrition regimen. Assessments, including safety and efficacy parameters, were performed on day 0 and after the last study infusion (day 29). Lipid peroxidation was determined by measurement of thiobarbituric acid reactive substances (TBARS).

Results: There were no significant differences in laboratory safety parameters, including liver enzymes, between the groups on day 29. The mean ± standard deviation changes in the total bilirubin concentration between the initial and final values (day 29 to day 0) were significantly different between groups: SMOFlipid group -1.5 ± 2.4 µmol/L vs SOE group 2.3 ± 3.5 µmol/L, P < .01; 95% confidence interval [CI], -6.2 to -1.4). In plasma and red blood cell (RBC) phospholipids, the ω-3 FAs C20:5ω-3 (eicosapentaenoic acid) and + C22:6ω-3 (docosahexaenoic acid) increased significantly in the SMOFlipid group on day 29. The ω-3:ω-6 FA ratio was significantly elevated with SMOFlipid 20% compared with SOE group (plasma, day 29: 0.15 ± 0.06 vs 0.07 ± 0.02, P < .01, 95% CI, 0.04-0.11; and RBC, day 29: 0.23 ± 0.07 vs 0.14 ± 0.04, P < .01, 95% CI, 0.04-0.13). Plasma α-tocopherol concentration increased significantly more with SMOFlipid 20% (15.7 ± 15.9 vs 5.4 ± 15.2 µmol/L, P < .05; 95% CI, -2.1 to 22.6). The low-density lipoprotein-TBARS concentrations were not significantly different between both groups, indicating that lipid peroxidation did not differ between groups.

Conclusions: SMOFlipid 20%, which contains 15% fish oil, was safe and well tolerated, decreased plasma bilirubin, and increased ω-3 FA and α-tocopherol status without changing lipid peroxidation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bilirubin / blood
  • Child
  • Child, Preschool
  • Cholesterol, LDL / blood
  • Dietary Fats / administration & dosage
  • Double-Blind Method
  • Fat Emulsions, Intravenous / administration & dosage*
  • Fat Emulsions, Intravenous / adverse effects
  • Fatty Acids, Omega-3 / blood*
  • Female
  • Fish Oils / administration & dosage*
  • Fish Oils / adverse effects
  • Humans
  • Infant
  • Lipid Peroxidation
  • Male
  • Olive Oil
  • Parenteral Nutrition, Home / methods*
  • Phospholipids / chemistry
  • Plant Oils / administration & dosage*
  • Plant Oils / adverse effects
  • Soybean Oil / administration & dosage*
  • Soybean Oil / adverse effects
  • Thiobarbituric Acid Reactive Substances
  • Treatment Outcome
  • Triglycerides / administration & dosage*
  • Triglycerides / adverse effects
  • alpha-Tocopherol / blood
  • alpha-Tocopherol / pharmacology

Substances

  • Cholesterol, LDL
  • Dietary Fats
  • Fat Emulsions, Intravenous
  • Fatty Acids, Omega-3
  • Fish Oils
  • Olive Oil
  • Phospholipids
  • Plant Oils
  • Thiobarbituric Acid Reactive Substances
  • Triglycerides
  • Soybean Oil
  • alpha-Tocopherol
  • Bilirubin