Lack of association between endoplasmic reticulum stress response genes and suicidal victims

Kaoru Sakurai; Naoki Nishiguchi; Osamu Shirakawa; Hideyuki Nushida; Yasuhiro Ueno; Kiyoshi Maeda; Yoshitake Hayashi

Lack of association between endoplasmic reticulum stress response genes and suicidal victims

Kobe J Med Sci. 2007;53(4):151-5.

Authors

Kaoru Sakurai¹, Naoki Nishiguchi, Osamu Shirakawa, Hideyuki Nushida, Yasuhiro Ueno, Kiyoshi Maeda, Yoshitake Hayashi

Affiliation

¹ Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment (ICMRT), Kobe University Graduate School of Medicine.

PMID: 17932454

Abstract

As lithium has been shown to have a protective effect against suicidal behavior, genes on which mood stabilizers act may be involved in biological susceptibility to suicide. A recent study showed that endoplasmic reticulum (ER) stress response was impaired in the bipolar disorders and the impairment was ameliorated by a mood stabilizer, valproate. We hypothesized that an alteration of ER stress response is involved in the biological susceptibility to suicide through genetic polymorphisms, and examined the association of polymorphisms of X-box binding protein 1 (XBP1) and heat shock 70-kDa protein 5 (HSPA5) genes with suicide. We found no significant difference in the distribution of these polymorphisms between the suicide victims and the controls. These results suggest that the polymorphisms examined in this study are not involved in the susceptibility to suicide of the Japanese.

Publication types

Comparative Study

MeSH terms

Adult
Bipolar Disorder / genetics
Bipolar Disorder / metabolism
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Endoplasmic Reticulum / genetics*
Endoplasmic Reticulum / metabolism
Endoplasmic Reticulum Chaperone BiP
Female
Heat-Shock Proteins / genetics
Heat-Shock Proteins / metabolism
Humans
Male
Middle Aged
Molecular Chaperones / genetics
Molecular Chaperones / metabolism
Nuclear Proteins / genetics
Nuclear Proteins / metabolism
Point Mutation
Polymorphism, Single Nucleotide
Regulatory Factor X Transcription Factors
Stress, Psychological / genetics*
Stress, Psychological / metabolism
Suicide*
Transcription Factors
X-Box Binding Protein 1

Substances

DNA-Binding Proteins
Endoplasmic Reticulum Chaperone BiP
HSPA5 protein, human
Heat-Shock Proteins
Molecular Chaperones
Nuclear Proteins
Regulatory Factor X Transcription Factors
Transcription Factors
X-Box Binding Protein 1
XBP1 protein, human