Abstract
Ganoderic acid, from Ganoderma lucidum, at 8 microg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg x d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).
MeSH terms
-
Animals
-
Antiviral Agents / pharmacology*
-
Cell Line
-
Cells, Cultured / virology
-
Drugs, Chinese Herbal / pharmacology*
-
Escherichia coli / chemistry
-
Hepatitis B / drug therapy*
-
Hepatitis B virus / drug effects*
-
Hepatitis, Animal / chemically induced
-
Hepatitis, Animal / microbiology
-
Hepatitis, Animal / prevention & control*
-
Heptanoic Acids / isolation & purification
-
Heptanoic Acids / pharmacology*
-
Humans
-
Lipopolysaccharides
-
Male
-
Mice
-
Models, Animal
-
Mycobacterium bovis
-
Reishi / chemistry
-
Virus Replication / drug effects
Substances
-
Antiviral Agents
-
Drugs, Chinese Herbal
-
Heptanoic Acids
-
Lipopolysaccharides