Early recognition of basal cell naevus syndrome

Eur J Pediatr. 2005 Mar;164(3):126-30. doi: 10.1007/s00431-004-1597-4. Epub 2004 Dec 10.

Abstract

The basal cell naevus syndrome is an autosomal dominant syndrome characterised by major manifestations such as basal cell carcinomas, jaw cysts, palmar or plantar pits, and intracranial calcifications. Early recognition is important in order to reduce morbidity due to cutaneous and cerebral malignancy and oromaxillofacial deformation and destruction, although diagnosis in infancy is rare. We describe three unrelated children with basal cell naevus syndrome who appeared to be the first patient in each family.

Conclusion: Our observations lead us to recommend looking for other manifestations of this disease in patients who present with cardiac fibroma, cleft lip/palate, polydactyly or macrocephaly. Bifid, fused or splayed ribs should be considered a major criterion of great help in establishing a diagnosis, particularly in young children.

Publication types

  • Case Reports

MeSH terms

  • Basal Cell Nevus Syndrome / diagnosis*
  • Basal Cell Nevus Syndrome / genetics
  • Child
  • Child, Preschool
  • Craniofacial Abnormalities / genetics
  • Female
  • Fibroma / genetics
  • Heart Neoplasms / genetics
  • Humans
  • Infant
  • Male
  • Mutation
  • Patched Receptors
  • Polydactyly / genetics
  • Pupil Disorders / genetics
  • Receptors, Cell Surface / genetics
  • Ribs / abnormalities

Substances

  • Patched Receptors
  • Receptors, Cell Surface