Cell biology of the intracellular infection by Legionella pneumophila

Maëlle Molmeret; Dina M Bitar; Lihui Han; Yousef Abu Kwaik

doi:10.1016/j.micinf.2003.11.004

Cell biology of the intracellular infection by Legionella pneumophila

Microbes Infect. 2004 Jan;6(1):129-39. doi: 10.1016/j.micinf.2003.11.004.

Authors

Maëlle Molmeret¹, Dina M Bitar, Lihui Han, Yousef Abu Kwaik

Affiliation

¹ Department of Microbiology and Immunology, University of Louisville College of Medicine, Louisville, KY 40292, USA.

PMID: 14738901
DOI: 10.1016/j.micinf.2003.11.004

Abstract

Legionella pneumophila has become a paradigm for facultative intracellular pathogens that modulate biogenesis of their phagosomes into replicative niches. The ability to alter host cell biology and tailor it into a hospitable host for intracellular proliferation is at the crux of the mechanism of pathogenesis of Legionnaires' disease.

Publication types

Review

MeSH terms

Animals
Apoptosis
Bacterial Proteins / genetics
Carrier Proteins / genetics
Cell Division / physiology
Eukaryota / microbiology
Eukaryota / physiology
Eukaryotic Cells / parasitology
Eukaryotic Cells / pathology
Humans
Legionella pneumophila / genetics
Legionella pneumophila / pathogenicity*
Legionella pneumophila / physiology
Legionnaires' Disease / etiology*
Legionnaires' Disease / microbiology
Membrane Proteins / genetics
Necrosis
Virulence

Substances

Bacterial Proteins
Carrier Proteins
DotA protein, Legionella pneumophila
Membrane Proteins