Abstract
A patient with primary hyperoxaluria who received a liver-kidney transplant is presented. A postoperative renal biopsy showed apparent tubular cell endocytosis of calcium oxalate crystals and cell proliferation, indicating that renal epithelial cells do not perceive urinary crystals as inert. Such cellular responses to crystals may have a role in nephrolithiasis.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Calcium Oxalate / metabolism*
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Cell Division
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Endocytosis*
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Epithelium / pathology
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Female
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Humans
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Hyperoxaluria / pathology*
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Hyperoxaluria / physiopathology
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Hyperoxaluria / surgery
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Kidney Failure, Chronic / pathology
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Kidney Failure, Chronic / physiopathology
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Kidney Failure, Chronic / surgery
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Kidney Transplantation
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Kidney Tubules / pathology*
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Kidney Tubules / physiopathology
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Liver Transplantation