Helicobacter pylori CagA--a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins

Microbes Infect. 2003 Feb;5(2):143-50. doi: 10.1016/s1286-4579(02)00085-0.

Abstract

Helicobacter pylori virulence factor CagA is injected into gastric epithelial cells and undergoes tyrosine phosphorylation. Similar to mammalian Gab protein, tyrosine-phosphorylated CagA recruits and activates SHP-2 phosphatase at the plasma membrane, thereby inducing a growth factor-like effect. CagA-SHP-2 interaction may play an important role in bacterial pathogenesis, leading to gastric carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / metabolism*
  • Bacterial Proteins / metabolism*
  • Epithelial Cells / microbiology
  • Epithelial Cells / pathology
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / physiopathology
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / physiopathology
  • Helicobacter pylori / pathogenicity*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Phosphoproteins / metabolism*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatases / metabolism*
  • Signal Transduction
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / physiopathology
  • Virulence

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • Intracellular Signaling Peptides and Proteins
  • Phosphoproteins
  • cagA protein, Helicobacter pylori
  • PTPN11 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatases